SNAPAP

SNAPIN

Identifiers

Aliases, BLOC1S7, BLOS7, SNAPAP, BORCS3, SNAP associated protein

External IDsOMIM: ; MGI: ; HomoloGene: ; GeneCards: ; OMA:

Gene location ( Human )

Chr.Chromosome 1 (human)

Band 1q21.3 Start 153,658,703 bp

End153,661,852 bp

Gene location ( Mouse )

Chr.Chromosome 3 (mouse)

Band 3|3 F1 Start 90,395,333 bp

End90,398,340 bp

RNA expression patternHumanMouse (ortholog)oocyte myocardium of left ventricle secondary oocyte cardiac muscle tissue of right atrium Skeletal muscle tissue of biceps brachii tibialis anterior muscle apex of heart quadriceps femoris muscle right adrenal cortex vastus lateralis musclecumulus cell temporal muscle muscle of thigh sternocleidomastoid muscle triceps brachii muscle utricle digastric muscle anterior horn of spinal cord quadriceps femoris muscle gastrocnemius musclen/a

RNA expression pattern

HumanMouse (ortholog)oocyte myocardium of left ventricle secondary oocyte cardiac muscle tissue of right atrium Skeletal muscle tissue of biceps brachii tibialis anterior muscle apex of heart quadriceps femoris muscle right adrenal cortex vastus lateralis musclecumulus cell temporal muscle muscle of thigh sternocleidomastoid muscle triceps brachii muscle utricle digastric muscle anterior horn of spinal cord quadriceps femoris muscle gastrocnemius muscle

Human Mouse (ortholog)

oocyte myocardium of left ventricle secondary oocyte cardiac muscle tissue of right atrium Skeletal muscle tissue of biceps brachii tibialis anterior muscle apex of heart quadriceps femoris muscle right adrenal cortex vastus lateralis musclecumulus cell temporal muscle muscle of thigh sternocleidomastoid muscle triceps brachii muscle utricle digastric muscle anterior horn of spinal cord quadriceps femoris muscle gastrocnemius muscle

cumulus cell temporal muscle muscle of thigh sternocleidomastoid muscle triceps brachii muscle utricle digastric muscle anterior horn of spinal cord quadriceps femoris muscle gastrocnemius muscle

n/a

Gene ontologyMolecular functionCellular componentBiological processSources: /

Gene ontology

Molecular function

Cellular component

Biological process

Sources: /

OrthologsSpeciesHumanMouseEntrez Ensembl UniProtRefSeq (mRNA)RefSeq (protein)Location (UCSC)PubMed search

Orthologs

Species Human Mouse

Entrez

Ensembl

UniProt

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

PubMed search

Wikidata

View/Edit HumanView/Edit Mouse

SNARE-associated protein Snapin is a protein that in humans is encoded by the SNAPIN gene.

Function

SNAPAP is a component of the SNARE complex of proteins that is required for synaptic vesicle docking and fusion. SNAPAP is also a component of the ubiquitously expressed BLOC1 multisubunit protein complex. BLOC1 is required for normal biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules.

Snapin has been established to be a promoter of vesicle docking, as it plays a role in binding to SNAP-25, which together stabilize and favor SNARE complex assembly and vesicle docking. Specifically, the degree to which snapin is necessary for proper synaptic release varies across species. The functions of snapin have been reported to be independent of synaptotagmin, and works through the SNAP-25 pathway to stabilize, prime, and dock vesicles.

Interactions

SNAPAP has been shown to interact with:

SNAPAP

Function

Interactions

Further reading