SULF2

Identifiers

Aliases, HSULF-2, sulfatase 2

External IDsOMIM: ; MGI: ; HomoloGene: ; GeneCards: ; OMA:

Gene location ( Human )

Chr.Chromosome 20 (human)

Band 20q13.12 Start 47,656,348 bp

End47,786,616 bp

Gene location ( Mouse )

Chr.Chromosome 2 (mouse)

Band 2|2 H3 Start 165,915,009 bp

End165,997,583 bp

RNA expression patternHumanMouse (ortholog)decidua body of uterus myometrium left ovary right ovary ectocervix left uterine tube monocyte tendon of biceps brachii smooth muscle tissuetail of embryo calvaria genital tubercle fossa umbilical cord condyle abdominal wall decidua endothelial cell of lymphatic vessel transitional epithelium of urinary bladdern/a

RNA expression pattern

HumanMouse (ortholog)decidua body of uterus myometrium left ovary right ovary ectocervix left uterine tube monocyte tendon of biceps brachii smooth muscle tissuetail of embryo calvaria genital tubercle fossa umbilical cord condyle abdominal wall decidua endothelial cell of lymphatic vessel transitional epithelium of urinary bladder

Human Mouse (ortholog)

decidua body of uterus myometrium left ovary right ovary ectocervix left uterine tube monocyte tendon of biceps brachii smooth muscle tissuetail of embryo calvaria genital tubercle fossa umbilical cord condyle abdominal wall decidua endothelial cell of lymphatic vessel transitional epithelium of urinary bladder

decidua body of uterus myometrium left ovary right ovary ectocervix left uterine tube monocyte tendon of biceps brachii smooth muscle tissue

tail of embryo calvaria genital tubercle fossa umbilical cord condyle abdominal wall decidua endothelial cell of lymphatic vessel transitional epithelium of urinary bladder

n/a

Gene ontologyMolecular functioncatalytic activityCellular componentBiological processSources: /

Gene ontology

Molecular functioncatalytic activity

Cellular component

Biological process

Sources: /

OrthologsSpeciesHumanMouseEntrez Ensembl UniProtRefSeq (mRNA)RefSeq (protein)Location (UCSC)PubMed search

Orthologs

Species Human Mouse

Entrez

Ensembl

UniProt

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

PubMed search

Wikidata

View/Edit HumanView/Edit Mouse

Extracellular sulfatase Sulf-2 is an enzyme that in humans is encoded by the SULF2 gene.

Function

Heparan sulfate proteoglycans (HSPGs) act as coreceptors for numerous heparin-binding growth factors and cytokines and are involved in cell signaling. Heparan sulfate 6-O-endosulfatases, such as SULF2, selectively remove 6-O-sulfate groups from heparan sulfate. This activity modulates the effects of heparan sulfate by altering binding sites for signaling molecules (Dai et al., 2005).[supplied by OMIM]

SULF2

Function

Further reading