The Francis Bowes Sayre Sr. Highway or simply the Sayre Highway is a four-to-six lane, 192-kilometre (119 mi), primary national highway that connects Cagayan de Oro to Kabacan. It traverses the provinces of Misamis Oriental, Bukidnon and Cotabato.

The highway's name was Route 3 but was changed to Sayre Highway, in honor of Francis Bowes Sayre, Sr., the U.S. Philippine High Commissioner who spearheaded its construction. It extends southward through central Mindanao for a distance of about 161 kilometers (100 mi), linking the northern and southern arms of Route 1 (Digos–Butuan Highway). This section of the Philippine national highway was constructed during the American occupation of the Philippines.

The parts of the highway are composed of National Route 10 (N10), a spur route of Asian Highway 26 in the north; and National Route 943 (N943) in the southern portion of the Philippine highway network.

Intersections

Intersections are numbered by kilometre post, with the Rizal Park in Manila designated as kilometre 0.

ProvinceCity/MunicipalitykmmiDestinationsNotes
Misamis OrientalCagayan de OroN9 (Butuan–Cagayan de Oro–Iligan Road)Northern terminus
BukidnonValenciaN912 (Kapalong–Talaingod–Valencia Road)
MaramagN945 (Maramag–Maradugao Road)
AH 26 (N10) (Bukidnon–Davao Road)Route number changes from N10 to N943.
CotabatoKabacanN75 (Davao–Cotabato Road)Southern terminus
1.000 mi = 1.609 km; 1.000 km = 0.621 mi Route transition