Serum response factor

SRF

Available structuresPDBOrtholog search:List of PDB id codes, ,

Available structures

PDBOrtholog search:

List of PDB id codes, ,

List of PDB id codes

, ,

Identifiers

Aliases, MCM1, serum response factor

External IDsOMIM: ; MGI: ; HomoloGene: ; GeneCards: ; OMA:

Gene location ( Human )

Chr.Chromosome 6 (human)

Band 6p21.1 Start 43,171,269 bp

End43,181,506 bp

Gene location ( Mouse )

Chr.Chromosome 17 (mouse)

Band 17|17 C Start 46,859,255 bp

End46,867,101 bp

RNA expression pattern

HumanMouse (ortholog)muscle layer of sigmoid colon left uterine tube popliteal artery tibial arteries right coronary artery saphenous vein body of uterus right auricle of heart gastric mucosa thoracic aortatail of embryo genital tubercle zygote muscle of thigh lip superior frontal gyrus granulocyte primary visual cortex dentate gyrus of hippocampal formation granule cell skeletal muscle tissue

Human Mouse (ortholog)

muscle layer of sigmoid colon left uterine tube popliteal artery tibial arteries right coronary artery saphenous vein body of uterus right auricle of heart gastric mucosa thoracic aortatail of embryo genital tubercle zygote muscle of thigh lip superior frontal gyrus granulocyte primary visual cortex dentate gyrus of hippocampal formation granule cell skeletal muscle tissue

muscle layer of sigmoid colon left uterine tube popliteal artery tibial arteries right coronary artery saphenous vein body of uterus right auricle of heart gastric mucosa thoracic aorta

tail of embryo genital tubercle zygote muscle of thigh lip superior frontal gyrus granulocyte primary visual cortex dentate gyrus of hippocampal formation granule cell skeletal muscle tissue

Gene ontologyMolecular functiontranscription factor activity, RNA polymerase II distal enhancer sequence-specific binding transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific bindingCellular componentBiological processSources: /

Gene ontology

Molecular functiontranscription factor activity, RNA polymerase II distal enhancer sequence-specific binding transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding

Cellular component

Biological process

Sources: /

OrthologsSpeciesHumanMouseEntrez Ensembl UniProtRefSeq (mRNA)RefSeq (protein)Location (UCSC)PubMed search

Orthologs

Species Human Mouse

Entrez

Ensembl

UniProt

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

PubMed search

Wikidata

View/Edit HumanView/Edit Mouse

Serum response factor, also known as SRF, is a transcription factor protein.

Function

Serum response factor is a member of the MADS (MCM1, Agamous, Deficiens, and SRF) box superfamily of transcription factors. This protein binds to the serum response element (SRE) in the promoter region of target genes. This protein regulates the activity of many immediate early genes, for example c-fos, and thereby participates in cell cycle regulation, apoptosis, cell growth, and cell differentiation. This gene is the downstream target of many pathways; for example, the mitogen-activated protein kinase pathway (MAPK) that acts through the ternary complex factors (TCFs).

SRF is important during the development of the embryo, as it has been linked to the formation of mesoderm. In the fully developed mammal, SRF is crucial for the growth of skeletal muscle. Interaction of SRF with other proteins, such as steroid hormone receptors, may contribute to regulation of muscle growth by steroids. Interaction of SRF with other proteins such as myocardin or Elk-1 may enhance or suppress expression of genes important for growth of vascular smooth muscle.

Clinical significance

Lack of skin SRF is associated with psoriasis and other skin diseases.

Interactions

Serum response factor has been shown to interact with:

External links

at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
FactorBook

This article incorporates text from the United States National Library of Medicine (), which is in the public domain.