TFCP2

Identifiers

Aliases, LBP1C, LSF, LSF1D, SEF, TFCP2C, transcription factor CP2

External IDsOMIM: ; MGI: ; HomoloGene: ; GeneCards: ; OMA:

Gene location ( Human )

Chr.Chromosome 12 (human)

Band 12q13.12-q13.13 Start 51,093,656 bp

End51,173,135 bp

Gene location ( Mouse )

Chr.Chromosome 15 (mouse)

Band 15 F1|15 56.33 cM Start 100,395,893 bp

End100,449,889 bp

RNA expression pattern

HumanMouse (ortholog)mucosa of paranasal sinus superficial temporal artery ventricular zone monocyte ganglionic eminence granulocyte rectum gastrocnemius muscle gonad islet of Langerhansneural layer of retina pineal gland genital tubercle tail of embryo ventricular zone perirhinal cortex renal corpuscle entorhinal cortex right kidney neural tube

Human Mouse (ortholog)

mucosa of paranasal sinus superficial temporal artery ventricular zone monocyte ganglionic eminence granulocyte rectum gastrocnemius muscle gonad islet of Langerhansneural layer of retina pineal gland genital tubercle tail of embryo ventricular zone perirhinal cortex renal corpuscle entorhinal cortex right kidney neural tube

mucosa of paranasal sinus superficial temporal artery ventricular zone monocyte ganglionic eminence granulocyte rectum gastrocnemius muscle gonad islet of Langerhans

neural layer of retina pineal gland genital tubercle tail of embryo ventricular zone perirhinal cortex renal corpuscle entorhinal cortex right kidney neural tube

Gene ontologyMolecular functionCellular componentBiological processSources: /

Gene ontology

Molecular function

Cellular component

Biological process

Sources: /

OrthologsSpeciesHumanMouseEntrez Ensembl UniProtRefSeq (mRNA)RefSeq (protein)Location (UCSC)PubMed search

Orthologs

Species Human Mouse

Entrez

Ensembl

UniProt

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

PubMed search

Wikidata

View/Edit HumanView/Edit Mouse

Alpha-globin transcription factor CP2 is a protein that in humans is encoded by the TFCP2 gene.

TFCP2 is also called Late SV40 factor (LSF) and it is induced by well-known oncogene AEG-1. LSF also acts as an oncogene in hepatocellular carcinoma. LSF enhances angiogenesis by transcriptionally up-regulating matrix metalloproteinase-9 (MMP9).

Along with its main oncogene function in hepatocellular carcinoma (HCC), it plays multifaceted role in chemoresistance, epithelial-mesenchymal transition (EMT), allergic response, inflammation and Alzheimer's disease. The small molecule FQI1 (factor quinolinone inhibitor 1) prevents LSF from binding with HCC DNA, which results in HCC cell death.

Interactions

TFCP2 has been shown to interact with APBB1 and RNF2.

TFCP2

Interactions

Further reading