TMEM66

SARAF

Identifiers

Aliases, FOAP-7, TMEM66, XTP3, HSPC035, store-operated calcium entry associated regulatory factor

External IDsOMIM: ; MGI: ; HomoloGene: ; GeneCards: ; OMA:

Gene location ( Human )

Chr.Chromosome 8 (human)

Band 8p12 Start 30,063,003 bp

End30,083,208 bp

Gene location ( Mouse )

Chr.Chromosome 8 (mouse)

Band 8|8 A4 Start 34,621,717 bp

End34,637,999 bp

RNA expression patternHumanMouse (ortholog)germinal epithelium endothelial cell corpus epididymis sperm Brodmann area 23 bronchial epithelial cell epithelium of nasopharynx pars compacta caput epididymis superior vestibular nucleusolfactory epithelium median eminence arcuate nucleus paraventricular nucleus of hypothalamus supraoptic nucleus seminal vesicula central gray substance of midbrain dorsomedial hypothalamic nucleus parotid gland islet of Langerhansn/a

RNA expression pattern

HumanMouse (ortholog)germinal epithelium endothelial cell corpus epididymis sperm Brodmann area 23 bronchial epithelial cell epithelium of nasopharynx pars compacta caput epididymis superior vestibular nucleusolfactory epithelium median eminence arcuate nucleus paraventricular nucleus of hypothalamus supraoptic nucleus seminal vesicula central gray substance of midbrain dorsomedial hypothalamic nucleus parotid gland islet of Langerhans

Human Mouse (ortholog)

germinal epithelium endothelial cell corpus epididymis sperm Brodmann area 23 bronchial epithelial cell epithelium of nasopharynx pars compacta caput epididymis superior vestibular nucleusolfactory epithelium median eminence arcuate nucleus paraventricular nucleus of hypothalamus supraoptic nucleus seminal vesicula central gray substance of midbrain dorsomedial hypothalamic nucleus parotid gland islet of Langerhans

germinal epithelium endothelial cell corpus epididymis sperm Brodmann area 23 bronchial epithelial cell epithelium of nasopharynx pars compacta caput epididymis superior vestibular nucleus

olfactory epithelium median eminence arcuate nucleus paraventricular nucleus of hypothalamus supraoptic nucleus seminal vesicula central gray substance of midbrain dorsomedial hypothalamic nucleus parotid gland islet of Langerhans

n/a

Gene ontologyMolecular functionCellular componentBiological processSources: /

Gene ontology

Molecular function

Cellular component

Biological process

Sources: /

OrthologsSpeciesHumanMouseEntrez Ensembl UniProtRefSeq (mRNA)RefSeq (protein)Location (UCSC)PubMed search

Orthologs

Species Human Mouse

Entrez

Ensembl

UniProt

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

PubMed search

Wikidata

View/Edit HumanView/Edit Mouse

SARAF is a protein that in humans is encoded by the SARAF gene, formerly known as TMEM66 (transmembrane protein 66).

Function

SARAF (TMEM66) is a negative regulator of the store-operated calcium channel (SOCE) into cells. SARAF is an endoplasmic reticulum (ER) membrane resident protein that associates with STIM1, to facilitate the inactivation of SOCE. SARAF plays a key role in shaping cytoplasmic calcium signals and determining the content of the major intracellular Ca2+ stores in the cell. By doing so it is likely to be important in protecting cells from calcium overfilling.

TMEM66

Function

Further reading