Ubiquitin conjugation factor E4 B is a protein that in humans is encoded by the UBE4B gene.

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s.

This gene encodes an additional conjugation factor, E4, which is involved in multiubiquitin chain assembly. This gene is also the strongest candidate in the neuroblastoma tumor suppressor genes.

Further reading

  • Onyango P, Lubyova B, Gardellin P, et al. (1998). . Genomics. 50 (2): 187–98. doi:. PMID .
  • Ohira M, Kageyama H, Mihara M, et al. (2000). "Identification and characterization of a 500-kb homozygously deleted region at 1p36.2-p36.3 in a neuroblastoma cell line". Oncogene. 19 (37): 4302–7. doi:. PMID . S2CID .
  • Mahoney JA, Odin JA, White SM, et al. (2002). . Biochem. J. 361 (Pt 3): 587–95. doi:. PMC . PMID .
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). . Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:. doi:. PMC . PMID .
  • Kaneko C, Hatakeyama S, Matsumoto M, et al. (2003). "Characterization of the mouse gene for the U-box-type ubiquitin ligase UFD2a". Biochem. Biophys. Res. Commun. 300 (2): 297–304. doi:. PMID .
  • Krona C, Ejeskär K, Abel F, et al. (2003). "Screening for gene mutations in a 500 kb neuroblastoma tumor suppressor candidate region in chromosome 1p; mutation and stage-specific expression in UBE4B/UFD2". Oncogene. 22 (15): 2343–51. doi:. PMID . S2CID .
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). . Nat. Genet. 36 (1): 40–5. doi:. PMID .
  • Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). . Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:. doi:. PMC . PMID .
  • Okumura F, Hatakeyama S, Matsumoto M, et al. (2005). . J. Biol. Chem. 279 (51): 53533–43. doi:. PMID .
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). . Genome Res. 14 (10B): 2121–7. doi:. PMC . PMID .
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). . Genome Res. 16 (1): 55–65. doi:. PMC . PMID .
  • Gregory SG, Barlow KF, McLay KE, et al. (2006). . Nature. 441 (7091): 315–21. Bibcode:. doi:. PMID .
  • Spinette S, Mahoney JA, Rosen A (2006). "The MPAC domain is a novel mitotically regulated domain, removed by apoptotic protease cleavage during cell death". Biochem. Biophys. Res. Commun. 347 (4): 1103–12. doi:. PMID .
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). . Cell. 127 (3): 635–48. doi:. PMID . S2CID .

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