UPF3B

Available structuresPDBHuman UniProt search:List of PDB id codes,

Available structures

PDBHuman UniProt search:

List of PDB id codes,

List of PDB id codes

Identifiers

Aliases, HMRX62, MRXS14, RENT3B, UPF3X, Upf3p-X, UPF3BP1, UPF3BP2, UPF3BP3, UPF3 regulator of nonsense transcripts homolog B (yeast), UPF3 regulator of nonsense transcripts homolog B, regulator of nonsense mediated mRNA decay, UPF3B regulator of nonsense mediated mRNA decay, MRX82

External IDsOMIM: ; MGI: ; HomoloGene: ; GeneCards: ; OMA:

Gene location ( Human )

Chr.X chromosome (human)

Band Xq24 Start 119,805,311 bp

End119,852,998 bp

Gene location ( Mouse )

Chr.X chromosome (mouse)

Band X|X A3.3 Start 37,091,678 bp

End37,110,322 bp

RNA expression pattern

HumanMouse (ortholog)sural nerve embryo cerebellar hemisphere ganglionic eminence endothelial cell amniotic fluid right hemisphere of cerebellum ventricular zone testicle visceral pleuraIleal epithelium Paneth cell neural layer of retina pineal gland medullary collecting duct retinal pigment epithelium epithelium of lens islet of Langerhans fossa substantia nigra

Human Mouse (ortholog)

sural nerve embryo cerebellar hemisphere ganglionic eminence endothelial cell amniotic fluid right hemisphere of cerebellum ventricular zone testicle visceral pleuraIleal epithelium Paneth cell neural layer of retina pineal gland medullary collecting duct retinal pigment epithelium epithelium of lens islet of Langerhans fossa substantia nigra

sural nerve embryo cerebellar hemisphere ganglionic eminence endothelial cell amniotic fluid right hemisphere of cerebellum ventricular zone testicle visceral pleura

Ileal epithelium Paneth cell neural layer of retina pineal gland medullary collecting duct retinal pigment epithelium epithelium of lens islet of Langerhans fossa substantia nigra

Gene ontologyMolecular functionCellular componentBiological processSources: /

Gene ontology

Molecular function

Cellular component

Biological process

Sources: /

OrthologsSpeciesHumanMouseEntrez Ensembl UniProtn/aRefSeq (mRNA)RefSeq (protein)n/aLocation (UCSC)PubMed search

Orthologs

Species Human Mouse

Entrez

Ensembl

UniProt n/a

n/a

RefSeq (mRNA)

RefSeq (protein) n/a

n/a

Location (UCSC)

PubMed search

Wikidata

View/Edit HumanView/Edit Mouse

Regulator of nonsense transcripts 3B is a protein that in humans is encoded by the UPF3B gene.

This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The encoded protein is one of two functional homologs to yeast Upf3p. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions. This gene is located on the long arm of chromosome X. Two splice variants encoding different isoforms have been found for this gene.

Interactions

UPF3B has been shown to interact with UPF2 and UPF1.

UPF3B

Interactions

Further reading