Kinase insert domain receptor (KDR, a type IV receptor tyrosine kinase) also known as vascular endothelial growth factor receptor 2 (VEGFR-2) is a VEGF receptor. KDR is the human gene encoding it. KDR has also been designated as CD309 (cluster of differentiation 309). KDR is also known as Flk1 (Fetal Liver Kinase 1).

The Q472H germline KDR genetic variant affects VEGFR-2 phosphorylation and has been found to associate with microvessel density in NSCLC.

Interactions

Kinase insert domain receptor has been shown to interact with SHC2, Annexin A5 and SHC1.

See also

Further reading

External links

  • at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
  • Overview of all the structural information available in the PDB for UniProt: (Vascular endothelial growth factor receptor 2) at the PDBe-KB.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.