In 1968, Whampoa Constituency was formed by carving out of Kallang Constituency. In 1988, it was renamed as Whampoa Single Member Constituency as part of Singapore's political reforms. It existed for another term until 1991 when it was abolished and divided into Kampong Glam, Jalan Besar and Toa Payoh Group Representation Constituencies.
In 2011, Whampoa Single Member Constituency was recreated by carving out from Jalan Besar Group Representation Constituency (GRC) as Jalan Besar GRC was dissolved and was replaced by Moulmein–Kallang and Tanjong Pagar GRCs respectively. Heng Chee How contested as a solo PAP candidate in the newly formed Whampoa SMC and won with 66.1% of the vote against the National Solidarity Party's Ken Sun. This was despite a national swing against the PAP. It was later merged back to the revived Jalan Besar GRC again in the 2015 Singaporean general election.
Note: The Elections Department does not include rejected votes when calculating the vote shares of candidates. Hence, all candidates' vote shares will total to 100% at any given election (may not appear so in multi-way contests due to rounding).