Yusufkhel (Pashto: يوسف خېل ولسوالۍ, Persian: ولسوالی یوسف‌خیل) or Yosuf Khel is a district of Paktika Province, Afghanistan. The estimated population in 2019 was 28,691.

33°03′00″N 68°38′45″E/33.05°N 68.6458°E/ 33.05; 68.6458