2CD-2,5-DiEtO, also known as 2,5-diethoxy-4-methylphenethylamine, is a psychoactive drug of the phenethylamine, 2C, and TWEETIO families related to the psychedelic drug 2C-D. It is the derivative of 2C-D in which the methoxy groups at the 2 and 5 positions have been replaced with ethoxy groups.

According to Alexander Shulgin in his book PiHKAL (Phenethylamines I Have Known and Loved) and other publications, 2CD-2,5-DiEtO's dose is greater than 55mg orally and its duration is 4hours. 2CD-2,5-DiEtO has been described as producing mild effects that were no greater than a "plus-one" on the Shulgin Rating Scale. No specific effects have been described and higher doses were not tested.

The chemical synthesis of 2CD-2,5-DiEtO has been described.

2CD-2,5-DiEtO was first described in the literature by Shulgin in PiHKAL in 1991. It was developed and tested by Darrell Lemaire, with publication via personal communication with Shulgin. The drug is a controlled substance in Canada under phenethylamine blanket-ban language.

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