DOM-2,5-DiEtO, also known as 2,5-diethoxy-4-methylamphetamine, is a drug of the phenethylamine, amphetamine, and DOx families related to the psychedelic drug DOM. It is the derivative of DOM in which the methoxy groups at the 2 and 5 positions have been replaced with ethoxy groups. The properties and effects of DOM-2,5-DiEtO in humans do not appear to be known. Similarly to DOM and DOET however, DOM-2,5-DiEtO has been reported to produce stimulant-like effects in rabbits. The drug was patented by Alexander Shulgin as a potential "CNS stimulant" in 1970. The chemical synthesis of DOM-2,5-DiEtO has been described. Close analogues of DOM-2,5-DiEtO, besides DOM, include Florence (DOM-2-EtO) and Iris (DOM-5-EtO), as well as 2CD-2,5-DiEtO.

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