HLA-DR2
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HLA-DR2 (DR2) of the HLA-DR serotype system, is a broad antigen serotype that is now preferentially covered by HLA-DR15 and HLA-DR16 serotype group. This serotype primarily recognizes gene products of the HLA-DRB1*15 and HLA-DRB1*16 allele groups.
Serology
| DRB1* | DR15 | DR2 | DR16 | Sample |
| allele | % | % | % | size (N) |
| 15:01 | 76 | 23 | 6428 | |
| 15:02 | 77 | 16 | 676 | |
| 15:03 | 81 | 13 | 286 | |
| 15:04 | >50 | 1 | ||
| 15:05 | >25 | 2 | ||
| 15:07 | >50 | 1 | ||
| . | ||||
| DR16 | DR2 | DR15 | N | |
| 16:01 | 41 | 29 | 19 | 703 |
| 16:02 | 47 | 30 | 16 | 239 |
| 16:04 | >50 | 1 |
Disease associations
DR2 serotypes are associated with Goodpasture syndrome, systemic lupus erythematosus, multiple sclerosis, narcolepsy, tuberculoid leprosy (multi-drug-resistant tuberculosis or leprosy), ulcerative colitis (Japanese), primary biliary cirrhosis and autoimmune hepatitis. DR2 is also found in all patients that test positive for anti-Asn-RNA-synthetase and chronic interstitial lung disease.
Genetic linkage
DR2 is linked to the HLA-DR51.