HLA-DR51
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| major histocompatibility complex, class II, DR51 | |
| Haplotypes groups | DRA*01:DRB5*01 DRA*01:DRB5*02 |
| Structure (See HLA-DR) | |
| Identifiers | alpha *0101 |
| Symbol(s) | [permanent dead link] |
| EBI-HLA | |
| Identifiers | beta 5 *01 *02 |
| Symbol(s) | [permanent dead link] |
| EBI-HLA | |
| EBI-HLA | 2011-05-15 at the Wayback Machine |
| Shared data | |
| Locus | chr.6 |
HLA-DR51 is a HLA-DR serotype that recognizes the antigens encoded by the minor DR locus HLA-DRB5.
DRB3, DRB4, and DRB5 are minor DR beta encoding loci, they have been recognized as having distinct evolution, having diverged from DRB1 approximately 4 million years ago.
DRB5 locus is only apparent in a small subset of DR haplotypes, and most individuals lack DRB5.
Alleles
| DRB5* | DR51 | ? | Sample |
| allele | % | % | size (N) |
| 0101 | >71 | 28 | |
| 0102 | >86 | 8 | |
| 0202 | >86 | 13 |
DRB5* is subdivided into two allele groups, DRB5*01 and DRB5*02. B5*01 encodes 14 alleles and 11 isoforms. B5*02 encoded 4 alleles that can generate 4 isoforms. Only 3 of these have been surveyed by serotyping. There are numerous null genes at this locus.
DRB5*01 allele group
- 14 Alleles: 11 proteins, 2 Nulls
- DR51 Serotype: *0101, *0102
- Serotype unknown: *0103 to *0107, *0109, *0110 to *0113
- Nulls: *0108N, *0110N
DRB5*02 allele group
- 4 Alleles: 4 proteins
- DR51 Serotype: *0202,
- Serotype unknown: *0203 to *0205
Associated diseases
DR51 serotype is positively associated with The following HLA-DRB5 alleles are associated with disease:
DRB5*0101:DRB1*1501 Multiple sclerosis, leprosy
DRB1 linkage
HLA-DRB5 (DR51)is linked to the following HLA-DR serotypes and DRB1 allele groups.