| 1465 | 1 | 6 January 2021 | London | Nadhim Zahawi, Anneliese Dodds, Mark Walport, Humphrey Cobbold, Rachel Clarke | COVID-19 special, broadcast at earlier time of 19:00. First edition with the QT50, a regular audience made up of people from across the UK. |
| 1466 | 2 | 14 January 2021 | Vicky Ford, Jon Ashworth, Philippa Whitford, Donna Kinnair, Mike Barton | |
| 1467 | 3 | 21 January 2021 | Northern Ireland | Brandon Lewis, Louise Haigh, Arlene Foster, Michelle O'Neill, Anand Menon | |
| 1468 | 4 | 28 January 2021 | London | Gillian Keegan, Kate Green, Layla McCay, Camilla Tominey, Deborah Meaden | This edition featured the first-ever all female panel in Question Time's history. |
| 1469 | 5 | 4 February 2021 | Oliver Dowden, Thangam Debbonaire, Wanda Wyporska, Robin Shattock, Wilfred Emmanuel-Jones | |
| 1470 | 6 | 11 February 2021 | Edinburgh | Michael Forsyth, Jeane Freeman, Ian Murray, Angela Haggerty, Stephen Fitzpatrick | |
| 1471 | 7 | 18 February 2021 | London | Mark Harper, Nadia Whittome, Layla Moran, Linda Bauld, Peter Borg Neal | |
| 1472 | 8 | 25 February 2021 | Grant Shapps, Anneliese Dodds, Tony Danker, Jo Grady, Jeremy King | |
| 1473 | 9 | 4 March 2021 | Kwasi Kwarteng, Lisa Nandy, Andy Palmer, Miatta Fahnbulleh, Theo Paphitis | |
| 1474 | 10 | 11 March 2021 | Mims Davies, Steve Reed, Victor Adebowale, Dan Hodges, Bonnie Greer | |
| 1475 | 11 | 18 March 2021 | Victoria Atkins, Jess Phillips, Kirsten Oswald, Mark Carney, Ian Hislop | |
| 1476 | 12 | 25 March 2021 | Cardiff | Vaughan Gething, Andrew RT Davies, Adam Price, Claire Fox, Nigel Owens | |
| 1477 | 13 | 15 April 2021 | London | Bernard Jenkin, Rosie Duffield, Geoff Norcott, Ayesha Hazarika, Xand van Tulleken | The edition ended with a tribute to Shirley Williams who had died earlier in the week and appeared on Question Time 58 times. |
| 1478 | 14 | 22 April 2021 | Edinburgh | Keith Brown, Douglas Ross, Anas Sarwar, Lorna Slater, Willie Rennie | |
| 1479 | 15 | 29 April 2021 | London | Anne-Marie Trevelyan, Jon Ashworth, Daisy Cooper, Tim Stanley, Danny Sriskandarajah | |
| 1480 | 16 | 6 May 2021 | Robert Jenrick, Thangam Debbonaire, Hugh Osmond, Deborah Frances-White, John Bercow | |
| 1481 | 17 | 13 May 2021 | Robert Buckland, Lisa Nandy, Kate Forbes, Michelle Dewberry, Paul Mason | |
| 1482 | 18 | 20 May 2021 | Nadhim Zahawi, Nick Thomas-Symonds, Richard Walker, Devi Sridhar, Harriet Green | |
| 1483 | 19 | 27 May 2021 | Grant Shapps, Emily Thornberry, Nadra Ahmed, Kate Clanchy, Tom Newton Dunn | |
| 1484 | 20 | 3 June 2021 | Lucy Frazer, Peter Kyle, Anthony Costello, Heather McGregor, Jenni Murray | |
| 1485 | 21 | 10 June 2021 | Gillian Keegan, Lucy Powell, Yanis Varoufakis, Kavita Oberoi, Frank Luntz | |
| 1486 | 22 | 17 June 2021 | Mark Harper, Sarah Jones, Ian Blackford, Daniel Finkelstein, Rosemary Squire | |
| 1487 | 23 | 24 June 2021 | Robert Buckland, Jon Ashworth, Caroline Lucas, Kate Andrews, Victor Adebowale | |
| 1488 | 24 | 1 July 2021 | David Davis, Andy Burnham, Chika Russell, Madeline Grant, Benjamin Zephaniah | |
| — | 25 | 18 August 2021 | James Cleverly, Lisa Nandy, Rory Stewart, Nelufar Hedayat, Mehdi Hasan | Afghanistan special. First edition since 12 March 2020 to have a live studio audience. |
| 1489 | 26 | 16 September 2021 | James Heappey, Kate Green, Nadra Ahmed, Nels Abbey, Andrew Neil | |
| 1490 | 27 | 23 September 2021 | Cambridge | Grant Shapps, David Lammy, Munira Wilson, Kate Andrews, Richard Walker | |
| 1491 | 28 | 30 September 2021 | Birmingham | George Eustice, Wes Streeting, Karan Bilimoria, Ella Whelan, Amy Hart | |
| 1492 | 29 | 7 October 2021 | Aldershot | Nadhim Zahawi, Lisa Nandy, Minette Batters, Nick Ferrari, Rosie Jones | |
| 1493 | 30 | 14 October 2021 | Nottingham | Penny Mordaunt, Alison McGovern, Robert Winston, Samuel Kasumu, Anne McElvoy | |
| 1494 | 31 | 21 October 2021 | Glasgow | Kate Forbes, Andrew Bowie, Anas Sarwar, Heather McGregor, Brian Cox | |
| 1495 | 32 | 28 October 2021 | Manchester | Lucy Frazer, Bridget Phillipson, Howard Davies, Miatta Fahnbulleh, Jenny Campbell | |
| 1496 | 33 | 4 November 2021 | Eastleigh | Paul Scully, Emily Thornberry, Caroline Lucas, Paul Polman, Tim Stanley | |
| 1497 | 34 | 11 November 2021 | Hartlepool | Lee Rowley, Lucy Powell, Emma Pinchbeck, Tom Newton Dunn, Alastair Campbell | |
| 1498 | 35 | 18 November 2021 | London | Mims Davies, Stella Creasy, Stephen Flynn, Nazir Afzal, Jordan Peterson | |
| 1499 | 36 | 25 November 2021 | Cardiff | Robert Buckland, Eluned Morgan, Liz Saville Roberts, Timandra Harkness, Guto Harri | |
| 1500 | 37 | 2 December 2021 | Weston-super-Mare | Maggie Throup, Thangam Debbonaire, Wendy Chamberlain, Peter Openshaw, Theo Paphitis | |
| 1501 | 38 | 9 December 2021 | London | Rachel Maclean, Anneliese Dodds, Steven Bartlett, Michael Portillo, Adjoa Andoh | |
| 1502 | 39 | 16 December 2021 | Stoke-on-Trent | Chris Philp, Lisa Nandy, Stewart Hosie, Olivia Utley, Chris Hopson | |