Zinc finger and BTB domain-containing protein 16

Zinc finger and BTB domain-containing protein 16 is a protein that in humans is encoded by the ZBTB16 gene.

Function

This gene is a member of the Krueppel C2H2-type zinc-finger protein family and encodes a zinc finger transcription factor that contains nine Kruppel-type zinc finger domains at the carboxyl terminus. This protein is located in the nucleus, is involved in cell cycle progression, and interacts with a histone deacetylase. Specific instances of aberrant gene rearrangement at this locus have been associated with acute promyelocytic leukemia (APL) and physiological roles have been identified in mouse Natural Killer T cells and gamma-delta T cells. Alternate transcriptional splice variants have been characterized in human.

Interactions

Zinc finger and BTB domain-containing protein 16 has been shown to interact with:

• Angiotensin II receptor type 1,
• BCL6,
• BMI1,
• Calcitriol receptor,
• FHL2,
• GATA1,
• GATA2,
• HDAC1,
• HDAC4,
• HDAC5,
• HDAC6,
• Heparin-binding EGF-like growth factor,
• Nuclear receptor co-repressor 2,
• Promyelocytic leukemia protein
• RUNX1T1,
• Retinoic acid receptor alpha,
• SIN3A,
• SIN3B, and
• ZBTB32.

See also

• Zbtb7

Further reading

External links

• at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.