RBBP7

Histone-binding protein RBBP7 is a protein that in humans is encoded by the RBBP7 gene.

Function

This protein is a ubiquitously expressed nuclear protein and belongs to a highly conserved subfamily of WD-repeat proteins. It is found among several proteins that binds directly to retinoblastoma protein, which regulates cell proliferation. The encoded protein is found in many histone deacetylase complexes, including mSin3 co-repressor complex. It is also present in protein complexes involved in chromatin assembly. This protein can interact with BRCA1 tumor-suppressor gene and may have a role in the regulation of cell proliferation and differentiation.

Interactions

RBBP7 has been shown to interact with:

• BRCA1,
• GATAD2B,
• HDAC1,
• MTA2,
• Retinoblastoma protein,
• SAP30, and
• SIN3A.

Further reading